1H77.J OLD [Haynes. 



Pupils contracted ; nictitating membrane drawn over tlie cornea. 85 seconds, 

 he staggered a few steps, fell on the side, and in 1^ min. was seized with 

 powerful tetanic convulsions, which terminated life at 4 min. 



Experiment 135. 



A dog, weighing 7 lbs., received Strychnia Sulph. gr. 1-33, with Nicmin 

 Tlftl-200. 1 min., labored respiration. 7 min., slight convulsion. 7^ 

 min., Nicotin 1111-300 given. 8 min., respiration labored and noisy. 

 ^min., tetanic convulsion. lOmin., Nicotin 1-300 given, limin., tetanic 

 convulsion, and death. 



Experiments 136, 137, 138. 



(136) A dog, weighing 3 lbs. 10 oz., received Strychnia Sulph. gr. 1-193. 

 Tlie symptoms were rigidity of the limbs, and slight increase of reflex 

 excitability, lasting till the 35^/i vii7i. 



(137) The same animal, 5 days afterward, received Nicotin TTL 1-1'J3. 

 The symptoms (which lasted about 30 minutes) were slow, labored respira- 

 tion, staggering gait, vomiting, salivation, contracted pupil. 



(138) The same animal, after 7 days, received the two drugs together, 

 in the doses detailed above. The symptoms were slow, labored respira- 

 tion, great weakness, staggering walk, vomiting, salivation, contraction of 

 pupil ; several slight convulsions between the 13th and 18th mins. 30 

 min., recovery. 



Experiments 139, 130, 131. 



(139) A dog, weighing 7 lbs., received Strychnia Sulph. gr. 1-48. It 

 was followed by stiffness and increased reflex excitability. When irritated, 

 feeble convulsions occurred. 



(130) The same animal, after 5 days, received Nicotin Tn.1-300. 2 

 min., respiration very difllcult ; gait staggering. 7 min., purging and 

 vomiting. 



(131) The same animal, 7 days afterwards, received the doses, detailed 

 in Experiments 139 and 130, combined. 3 min., difticult respiration, and 

 staggering gait. 9 mi7i., vomiting ; great rigidity. 13 to 30 min., irregu- 

 lar convulsions occurred spontaneously ; gradual recovery. 



Experiments 132, 133, 134. 



(133) A dog, weighing 5 lbs. 10 oz., received Strychnia Sulph. gr. 1-96. 

 15 min., decided stiffness and difficulty in walking ; somewhat labored 

 respiration. 38 mi?i., recovering. 



(133) The same animal, 6 days afterwards, received Nicotin TrLl-200, 

 with the same effect as in Experiment 130. 



(134) The same animal, 7 daj's afterwards, received the two poisons 

 combined in the doses detailed above. Ij min., difficult respiration. 7 

 min., stiffness. 8 min., vomiting; convulsive movements. 13 and 15 

 min., irregular convulsions. 33 min., recovering. 



PROC. AMER. PHILOS. SOC. XVI. 99, 3y 



