HnvMes. 014: [March Hi. 



EXPEKIMENTS 135, 136, 137. 



(135) A dog, weighing 2^ lbs., received Strychnia Suljih. gr. 1-180, 

 with tlic cirecls mentioned in Experiment 126. 



(13G) Tlie .siime dog, days aferwards, received Nicotin 1TL1 l'*~> with 

 tlie cfl'ects described in Experiment 127. 



(137) The same animal, 2 weeks afterwards, weighing then 4^11)8., re- 

 ceived the two poisons combined, in the doses mentioned in the two i)re- 

 ceding experiments. 1 min., panting respiration. 4 min., lay quietly, as if 

 exhausted. 12 min., vomiting. 29 min., decided rigidity. He stood 

 with his head in a corner, moaning. Though the animal had much in- 

 creased in weight, the symptoms were more marked than in the controlling 

 experiments. 



Experiments 138, 139, 140. 



(138) A dog, weighing 11 lbs., received Strychnia Sulph. gr. 1-48, with 

 no effect. 



(139j The same animal, after 6 days, received Nicotin Tni-20. \min., 

 difficult respiration. 2 min., staggeiing gait. 15 ?rt»i., recovering. 



(140) Tiie same animal, 7 days after, received Nicotin Tlll-20. Im- 

 mediately, the animal became almost completely paralyzed, and breathed 

 noisily and laboriously. 1 min.. Strychnia Sulph gr. 1-9G was injected. 

 Clonic convulsions set inafier a fewseconds, and continued for H minute. 

 During the convulsion, a second injection of Strychnia Suli>h. gr. 1.96 

 (making in all gr. 1-48) was given. 1^ min., convulsions ceased; tem- 

 porary cessation of respiration, which recommenced with a gasp, and for 

 5 minutes was very laborious and infrequL-nt (5 to 10 perniiMute). During 

 this time, the animal remained completely paralyzed and unconscious. 7^ 

 min., he staggered across the room ; respiration improving ; pupil con- 

 tracted, and nic.itating membrane drawn. 21 min., tlie animal now stood 

 in a stifl, uneasy attitude, quivering very much when touched, and every 

 minute running across the room, howling, .slightly convulsed. 38 min., 

 he was lifted slightly with tlie foot, and fell over on his side in a violent 

 clonic convulsion. After this, no more convulsions occurred. Tiu; animal 

 gradually recovered. * 



EXPEUIMENT 141, 142, 143. 



(141) A dog, weighing 14 lbs., received Strychnia Sulpli. gr. 1-24. It 

 was followed by marked increase of reflex excitability, lasting 75 min- 

 utes. The animal barely escaped a convulsion. 



(142) Tlie same animal, one week after, received Nicotin tlll-20, with 

 the. effects noted under Experiment 139. 



(143) The same an'mal, one week after, received the two poisons com- 

 bined, in the do.sos just detailed. 5 min., difficult respiration, great rigid- 

 ity, vomiting. 15 min., severe clonic convulsions lasting two minutes. 

 23 to 35 mm., he had numerous convulsions, but none strong enough to 

 cause him to fall. Then a powerful tetanic convulsion occurred ; then the 

 same condition of semi-convulsion was noted ; and at 45 min., another 

 tetanic convulsion, and death. 



