84 



CRILE— PHYLOGENETIC ASSOCIATION 



[April 22, 



heavy strain lie became increasingly more nervous, and impercep- 

 tibly there appeared a pulsating enlargement of the thyroid gland, 

 an increased prominence of the eyes, marked increase in perspira- 

 tion, even profuse sweating, palpitation of the heart, increased res- 

 piration with frequent sighing, increase in blood pressure; there was 

 tremor of many muscles, rapid loss of weight and strength, fre- 

 quent gastro-intestinal disturbances, loss of normal control of his 

 emotions, and marked impairment of his mental faculties. He was 

 as completely broken in health as in fortune. These phenomena 



Fig. 4. This picture is taken from Darwin's " Expression of the Emotions 

 in Man and Animals " and expresses horror and agony. 



resembled closely those of fear and followed in the wake of strain 

 due to fear. 



In young women exopthalmic goiter often follows in the wake of 

 a disappointment in love ; in women, too, it frequently follows in 

 the wake of an illness of a child or parent in which the double 

 strain of worry and of constant care is present. Since such strains 

 usually fall heaviest upon woman, they are the most frequent 

 victims. Now, Avhatever the exciting cause of exophthalmic goiter, 

 whether unusual business worry, disappointment in love, a tragedy, 

 or the illness of a loved one, the symptoms are alike and closely 

 resemble the phenomena of one of the great primitive emotions. 

 How • could disappointment in love play a role in the causation 

 of Graves' Disease? If the hypothesis presented for the explana- 



