NINTH ANNUAL YEAR BOOK— PART IX 383 
forcement of quarantine regulations, however, to keep the disease within 
the herd. It is believed the disease was taken from among other stock 
in South Dakota. 
Shortly after the above outbreak, another case was reported from 
Nevada, where a herd of horses and mules were found afflicted with the 
disease. Fifty-eight horses and mules were immediately quarantined, 
and several of them died or were destroyed. After making the proper 
tests, and finding that subsequent developments indicated the quarantined 
animals were not affected, they were released from quarantine. 
Another call in May of 1907, from New Liberty, Iowa, developed five 
diseased out of a herd of thirty-two, and these were destroyed. 
During the spring of 1907, an outbreak occurred near Kellerton, which 
was traced to a carload of western horses sold to various farmers in 
that vicinity. The disease was found to exist at seven different farms, 
and more than a dozen horses and mules were destroyed or died from the 
effects of this disease. One interesting feature of this case was, that from 
this shipment of western horses, another and more severe outbreak oc- 
curred near Cummings, where one farmer lost fourteen head of horses 
and mules. At the time our attestion w^as called to these cases, four of 
the animals had died from the disease. Twelve head were tested, ten 
reacting to the test. Seven of this number showing symptoms were 
promptly destroyed by the owner. The other three were isolated and 
kept in quarantine, and in about ninety days the disease developed and 
they w^ere destroyed. The owner deserves a great deal of credit for 
generous and prompt action in destroying all animals found diseased, 
and thoroughly disinfecting the premises to prevent further spread. He 
kept over one hundred horses on his farm, and through his hearty co- 
operation no further evidence of the disease has developed. 
During the early part of April, 1907, and prior to this time, we re- 
ceived calls from Clinton where several cases of glanders were reported. 
Investigations had developed no less than 26 cases of the disease, and 
among them were the horses used by the Clinton Transfer Company. An 
effective system of quarantine operative for a period of about two years, 
finally resulted in completely destroying all existence or trace of the dis- 
ease. 
But the most distressing result of this outbreak was the death of 
Thomas Farrel, aged 35, who was a driver for the transfer company, and 
had contracted the disease from horses he had driven and cared for. 
So seldom does it occur that glanders has been transmitted from animal 
to man, that this was a case which required the most careful considera- 
tion. During I\Ir. Parrel's sickness, and in the month of July, 1907, the 
time of his demise, it became known for the first time that he had been 
exposed to the disease through attending horses which w^ere known to 
have had glanders. We were called upon then for our co-operation in 
determining exactly the nature of Mr. Farrel's sickness. The disease 
first made its appearance about the head and shoulders of the patient, 
thence it developed into pimples or pustules, showing in the glands and 
throat. There were symptoms at that time of malaria or septic poisoning. 
Associating the symptoms of Mr. Farrell wdth those of the diseased 
horses, it was found that the similarity justified further diagnosis. Micro- 
