REACTIONS OF THE SPOTTED NEWT 203 



animals' mouth where, as in the case of the clean cotton, it was 

 held for two minutes. When the animal was returned to the 

 water it paid no attention to the meat, nor to a i% acetic acid 

 solution. After five minutes it still paid no attention to the 

 meat, but gave a weak response to i% acetic acid. Half an 

 hour later it was still indifferent to the meat but gave a fairly 

 strong response to the acid. Two and a quarter hours after this 

 it still refused the meat, but an hour later it again snapped at 

 the meat, and continued to do so at intervals of an hour for the 

 rest of the day, as though it had entirely recovered from the. 

 effects of the cocaine. The next day both of these animals 

 refused to eat. 



The third animal acted in about the same way as the two 

 that have been described , except that on the second day it seemed 

 to recover from the effects of the cocaine in a much shorter time 

 than did the first two animals. After the first application of 

 cocaine it failed to respond to meat for about three hours. 



The fourth animal on the first day reacted as did the three 

 preceding, but on the second day after removal of the clean 

 cotton the animal refused to eat though tiied at intervals for 

 more than two hours. Whether the cotton had anything to do 

 with this reaction cannot be said with certainty. Two days 

 later this animal, after snapping at a piece of meat, was removed 

 from the water and its nostrils were painted for three minutes 

 with a 5% solution of cocaine, a camel's hair brush being used. 

 On being returned to the water it refused meat for more than 

 half an hour. 



The fifth animal after removal of the clean cotton from its 

 mouth refused meat for only a few minutes then snapped at it. 

 It was then removed from the water and its nostrils painted, as 

 in the preceding animal, with cocaine; it then refused meat for 

 the rest of the afternoon, though offered it at intervals for more 

 than two hours. Two days later this animal after being treated 

 with cocaine in the same way snapped at the meat in less than 

 half an hour after being returned to the water. 



The sixth animal on three occasions, after snapping at the 

 meat, was treated with the cocaine as in the preceding animal, 

 i.e., had its nostrils painted with the 5% solution. On two of 

 these occasions the animal snapped at the meat in half an hour 



