JOURNAL OP THE COLLEGE OF SCIENCE, IMPERIAL UNIVERSITY, 

 TOKYO, JAPAN. 



VOL. XXV., ARTICLE 17. 



Formation of ; -Oxycarbostyril from 

 o-Nitrobenzoylacetic Acid. 



By 

 Köichi Matsubara, RigaMsM. 



r-Oxycarbostyril or 2 : 4-dihyclroxyquinoline, 



OH 



or 



the inner anhydride of o-aminobenzoylacetic acid, was first ob- 

 tained by Baeyer and Bloem (Ber., 1882, 15, 2151), by heating 

 o-aminophenylpropiolic acid with concentrated sulphuric acid to 

 145°, in their attempt to prepare o-arainobenzoylacetic acid. 

 Owing to the close relationship which exists between o-amino- 

 benzoylacetic acid and several members of the indigo grouj), many 

 other investigators have attempted to prepare this acid. All these 

 attempts have, however, been unsuccessful, the product being 

 always found to be r-oxycarbostyril, which can also be obtained 

 in other ways. Thus it was obtained by Friedlander and 

 Weinberg (Ber., 1882, 15, 2G83) by the potash-fusion of j-chloro- 

 or r-bromo-carbostyril ; by Bischöfe (Ber., 1889, 22, 387 ; Ann., 

 1889, 251, 377), by the reduction of ethyl o-nitrobenzoylacetate 



