(584 CARREL— FURTHER STUDIES ON [November 6. 



By using the method of transplantation in mass it becomes pos- 

 sible to perform the transplantation of a whole anatomic region, 

 with its main artery and vein. From a first dog, the right part of 

 the scalp and the auricle were extirpated in one mass wtih the car- 

 tilaginous portion of the auditory canal cut close to the skull, the 

 connective tissue and the glands of the retro-maxillaris space, the 

 tissues of the carotid region, and the upper portions of the external 

 jugular vein and of the common carotid artery. On a second dog 

 the auricle and a portion of the scalp was extirpated and the right 

 part of the neck opened through a longitudinal incision. The ana- 

 tomic specimen was then placed close to the wound, and the periph- 

 eral end of the carotid artery and of the jugular vein united to the 

 central end of the corresponding vessels of the host, at the level of 

 the middle part of the neck. The circulation was then reestablished. 

 Then the neck was closed by two rows of suture. A few minutes 

 after the establishment of the circulation the ear and the scalp 

 assumed their normal appearance. The new ear was fixed by cir- 

 cular suture of its cartilaginous canal to the cartilaginous canal of 

 the host. The auricular muscles were sutured and the operation 

 completed by continuous catgut suture of the skin without drainage. 



Three weeks after the operation the auricle and the transplanted 

 tissues were in normal condition. The temperature of both auricles, 

 normal and transplanted, were about the same. The transplanted 

 ear was as thin and glossy as the normal one. Except for the dif- 

 ference of color, it could not have been seen that the ear did not 

 belong to the dog. 



The transplantation of a limb from one animal to another of the 

 same species is a problem very much simpler than the transplanta- 

 tion of a gland. In April, 1907, I found that a thigh, extirpated 

 from the fresh cadaver of a dog, and transplanted onto another dog, 

 could begin to heal in a very satisfactory manner. One year after, 

 by using more careful asepsis in the transplantation of the leg from 

 one fox terrier to another, I observed union by first intention of the 

 new leg to its host. 



A white, middle-aged male fox terrier w^as etherized and the left 

 leg cut just below the knee. The limb was perfused with Locke's 

 solution, wrapped in a greased silk towel and kept on a table at the 



