igoS] TRANSPLANTATION OF VESSELS AND ORGANS. 685 



temperature of the laboratory. A white, young female fox terrier 

 was etherized. She was of the same size and shape as the first dog. 

 Her nails and bones were very slightly smaller. The leg was ampu- 

 tated circularly just below the knee. The new leg was immediately 

 fixed to the central end of the tibia of the host by an Elsberg's alu- 

 minum splint. The muscles, nerves and femoral vessels were united 

 to the corresponding parts of the host, and the circulation reestab- 

 lished. A small exploratory incision was made between the second 

 and third toes. Hemorrhage of red blood occurred. The animal 

 recovered quickly and remained in normal condition. The tempera- 

 ture of the new foot was at first higher than that of the normal one. 

 It was also edematous. After a few days the edema disappeared 

 and the foot had exactly the same appearance as the normal one. 

 The temperature went slightly down. There was only a difference 

 of one tenth of a degree centigrade between the normal and the 

 new foot. 



Fifteen days after the operation the new leg was perfectly healed 

 by first intention, but the bones were not very strongly united. The 

 Elsberg splint had broken and the tibia was a little incurved. The 

 exploratory incision of the foot, although having been slightly in- 

 fected, was completely cicatrized. The new leg had the same 

 appearance as the normal one. The animal was in good condition, 

 but coughed a little. At this time several other dogs died of 

 broncho-pneumonia. The animal became sick. Twenty days after 

 the operation her condition became worse and a marked dyspnea 

 appeared. The dog died on the twenty-second day after the opera- 

 tion. Postmortem examination showed a double diffuse broncho- 

 pneumonia. The new leg was perfectly healed ; with linear cutane- 

 ous scars. Its appearance was exactly the same as the normal leg. 

 The bones were strongly united by a fibrous callus. The explora- 

 tory incision of the foot had healed without visible scar. 



This experiment is the first example of successful grafting of 

 a new limb on an animal. It demonstrates that the leg, in spite of 

 the change of owner, remains normal. If further experiments show 

 that the functions of the transplanted limb are normally reestab- 

 lished, it will be permissible to try on man the transplantation of 



