NUTRITION — BENEDICT, CHITTENDEN, MENDEI.. 213 



nate all muscular work and to so adjust the conditions of the experiment that 

 the different days and different periods might be wholly comparable. The 

 records of pulse, respiration, body temperature, and body weight were taken 

 in all experiments, and in the majority of experiments the urine was col- 

 lected in two-hour periods and the nitrogen determined. Determinations of 

 nitrogen and heat of combustion were made in the food. The data secured 

 by this series of experiments are to be amplified by those from others now 

 in progress and will ultimately appear as a report. 



The third line of investigation involved the development and testing of a 

 form of respiration apparatus for obtaining the respiratory exchange in short 

 periods. The apparatus, which is a modified form of the larger respiration 

 apparatus, has been perfected, and check tests made with it showed most 

 satisfactory results. On the basis of the experimental apparatus as devel- 

 oped, a more permanent apparatus is now being constructed. The discussion 

 of the apparatus and check tests, as well as experiments made on man, wnll 

 appear later in the form of a report. 



Chittenden, Russell H., Sheffield Scientific School, Yale University, New 

 Haven, Connecticut. Grants Nos. 264 and 348. Study of the miniynal 

 proteid reqicirement of high-proteid animals. (For previous reports see 

 Year Book No. 3, p. 131, and Year Book No. 4, p. 259.) $3.700- 



Report. — These grants have been used in ascertaining the minimal proteid 

 requirement of healthy dogs as types of high-proteid animals. A large 

 number of experiments on healthy dogs has been carried out for periods up to 

 a year in length, with a study of the effects produced by a gradual diminu- 

 tion of proteid food, together with a diminution of non-nitrogenous food. 

 Contrary to the oft-quoted experiments of Munk, Rosenheim, and Jagerroos, 

 it has been found possible to keep dogs alive and apparently in good condition 

 for a period of at least a year on relatively small amounts of proteid and with 

 a comparatively low intake of non-nitrogenous food. 



The experiments are practically concluded, the chemical work completed, 

 but there remains to be finished a histological study of the tissues of the 

 animals experimented with. Until the results of these examinations are 

 known the report combining the various conclusions can not well be written. 

 It is expected that a full and detailed report can be published this year. 



Mendel, Lafayette B^ Sheffield Scientific School, Yale University, New Haven, 



Connecticut. Grant No. 265. Study of the physiology of growth, especially 



ill its cheviical processes. (For previous report see Year Book No. 4, 



pp. 259-260.) $2,000. 



Experimental work under this grant is progressing, but it will be several 



months before the data are compiled satisfactorily so as to admit of any 



general statements. The study of the changes in composition incidental to 



diet are temporarily completed and at present work on the chemistry and 



physiology of the purin bodies in embryonic life is being carried on. 



