NUTRITION LABORATORY. 247 



ologists owe a great debt to the senior Tigerstedt for his accurate 

 translations of the reports of much American work that otherwise is 

 disregarded by foreign writers. Dr. Klas Sonden, whose ingenious 

 gas-analysis apparatus made possible the extensive study of the 

 composition of the atmosphere recently completed in the Nutrition 

 Laboratory, and Professor Johansson, whose studies in muscular 

 work, fasting, and the ingestion of carbohydrates have been continu- 

 ally referred to in our work, assured a profitable visit to Stockholm. 



At Copenhagen the laboratories of Krogh and Hasselbalch were 

 visited. The large chamber for reduced pressures in the Finsen lab- 

 oratory should lead to an illuminating series of researches. For the 

 first time the laboratories of Professors Hamburger in Groningen and 

 Professor Pekelharing in Utrecht were visited. American ideas of 

 "luxury" were far exceeded in the equipment of the new buildings 

 of Groningen. The Groningen Institute was well selected as the 

 meeting-place for the Ninth International Congress of Physiologists. 

 The researches on creatinine from the modest laboratory of Utrecht 

 are of special value in interpreting the results of the long fasting 

 experiment carried out last year at the Nutrition Laboratory. 



The possibilities of the Thoma oscillograph have been admirably 

 shown by Professor A. D. Waller, of London University, the pioneer 

 in the study of the electrical action of the heart. Time was taken 

 to secure sufficient evidence as to the practicability of the Thoma 

 instrument to warrant its purchase for the laboratory. It is quite 

 beyond the confines of this report to give an adequate statement of 

 the innumerable benefits received during this trip or of the friendly 

 interest shown in the Nutrition Laboratory. 



Through the kindness of Professor Agazzotti, director of the 

 laboratory in Turin, Mr. H. L. Higgins, of our staff, spent several 

 weeks at Col d'Olen on Monte Rosa, working under the direction of 

 Professor Galeotti, of Naples. On this tour Mr. Higgins likewise 

 visited the laboratories of Oxford and Copenhagen and enjoyed for 

 a time the courtesy of Professor Zuntz's laboratory in Berlin. 



INVESTIGATIONS IN PROGRESS. 

 METABOLISM IN DIABETES MELLITUS. 



Having successfulh' demonstrated the increased metabolism in 

 severe diabetes and the coincidence of this increased metabolism 

 with acidosis, several problems in relation to diabetes and metab- 

 olism presented themselves. Relatively few experiments were pos- 

 sible, owing to the difficulty of securing patients in the particular 

 stages of the disease required for studying the several points, but a 

 respiration apparatus was installed at the N. E. Deaconess Hospital 

 and respiration experiments were there carried out on diabetics. 



