296 CARNEGIE INSTITUTION OF WASHINGTON. 



weight, although with "normal" children the plotted chart gave indications 

 of an approximately regular line. As many of the infants were under weight, 

 the total metabolism was compared with the normal weight for the age, also 

 the expected weight computed from the birth-weight and normal growth 

 thereafter, but no approach to uniformity or regularity was apparent. 



A discussion of the supposed relationship between body-surface and metab- 

 olism and a critique of the methods used for measuring body-surface introduce 

 the discussion of the values found with these infants. No relationship was 

 found between the age of the infants and the heat produced per square meter 

 of body-surface, nor could any relationship be noted between the heat-pro- 

 duction per square meter of body-surface and the actual body-weight, the 

 normal weight for the age, or the expected body-weight. 



Evidence secured with normal and atrophic infants of different ages and 

 weights is presented to show that the active mass of protoplasmic tissue deter- 

 mines the heat-production. This active mass of protoplasmic tissue may be 

 stimulated to a greater or less cellular activity, the intensity of the stimulus 

 being indicated by the pulse-rate. 



(3) Studies in the respiratory exchange of infants. Francis G. Benedict and Fritz B. 



Talbot. Am. Jour. Diseases of Children, 8, p. 1 (1914). 



The results reported in Publication No. 201 of the Carnegie Institution of 

 Washington are given in this paper and further elaborated by the addition of 

 data more recently obtained, including especially that for numerous new-born 

 infants. 



(4) The basal gaseous metabolism of normal men and women. Francis G. Benedict, Louis 



E. Emmes, Paiil Roth, and H. Monmouth Smith. Jour. Biol. Chem.; 18, 

 p. 139 (1914). 



A large number of experiments on so-called "normal" individuals have been 

 made during the past seven years for the purpose of comparison with patholog- 

 ical and other subjects. The results of these observations which, at the time 

 of printing, had been obtained with 89 men and 68 women, are presented in 

 this paper in tabular form, the data including the age of the subjects, the 

 number of days under observation, the number of experimental periods used 

 in averaging the results, the body-weight without clothing, the height, the 

 carbon-dioxide production and oxygen consumption per minute and per kilo- 

 gram per minute, the pulse-rate, and the total heat computed for 24 hours 

 per kilogram of body- weight and per square meter of body-surface. Normal 

 individuals are here assumed to be "people in presumably good health." 

 This collection of data represents a preliminary attempt to provide a metab- 

 olism standard for people of different heights, weights, ages, and sex. 



(5) A study of prolonged fasting. Francis G. Benedict. Publication No. 203, Carnegie 



Institution of Washington (1914). 



In the spring of 1912 an experiment was made on a subject, A. L., who 

 subsisted for 31 days without food, drinking during that period only 750 c.c. 

 of distilled water per day. Observations were also made for 4 days prior to the 

 fast and imperfect observations for 3 days subsequent to it. The main object 

 of the investigation was to determine simultaneously as many factors in the 

 physiology of the subject as possible. 



The research included physical examinations by a physician, accompanied 

 by photographic studies and careful anthropometric measurements; records 

 of the body- weight, rectal temperature, pulse-rate, and blood pressure; a 



