278 CARNEGIE INSTITUTION OF WASHINGTON. 



COOPERATING AND VISITING INVESTIGATORS. 



Since the investigation in diabetes mellitus has become such a 

 relatively important factor in the researches of the Nutrition Labora- 

 tory and a clinical respiration apparatus has been installed in the 

 New England Deaconess Hospital, Professor Elliott P. Joslin, who has 

 cooperated in tliis research for the past seven years, has devoted more 

 than usual of his own tune and that of his assistants to a continuation of 

 the study. Dr. Joslin's activity in this field has recently been signalized 

 by the publication of a treatise on diabetes melhtus, which suimnarizes 

 in large measure many of the researches that have been carried out in 

 this laboratory and gives his experience with some 1,000 cases. 



Dr. Fritz B. Talbot, having made satisfactory arrangements with 

 the Massachusetts Wet Nurse Directory, has taken charge of the 

 researches on the metabolism of normal infants, i. e., the children of 

 healthy, inspected wet nurses. 



Dr. George P. Denny, cooperating with Dr. F. M. Allen, of the 

 Rockefeller Hospital, has contributed to the general research on 

 diabetes by making observations on the gaseous metabolism of partially 

 depancreatized dogs prior to and subsequent to sugar feeding. Dr. 

 Demiy's departure for the war zone in Europe has indefinitely post- 

 poned the completion of these observations. 



Dr. J. Arthur Harris, of the Station for Experimental Evolution, Cold 

 Spring Harbor, visited the Laboratory and was present at several con- 

 ferences in New York City with regard to the statistical treatment of 

 certain of the data thus far accumulated by the Laboratory. Dr. 

 Harris's cooperation in the statistical handling of this material is taking 

 an active form. 



INVESTIGATIONS IN PROGRESS. 



In accordance with the usual custom the investigations now actively 

 in progress in this Laboratory are outlined herewith. 



METABOLISM DURING MUSCULAR WORK. 



The research on energy transformations during walking, which was 

 begun by Doctors C. Tigerstedt and H. Murschhauser in 1913-14 on 

 horizontal walking and continued by Dr. H. M. Smith in 1914-15 on 

 gi'ade walking, has been concluded, and the results of Dr. Smith's inves- 

 tigations are being tabulated. The Laboratory has been fortunate 

 in having as subject a young man who has faithfully fulfilled the require- 

 ments of a hard forenoon's walk upgrade without breakfast. These 

 observations were continued throughout the whole year, except for a 

 brief period when the subject developed a tendon strain and it became 

 necessary for hun to be relieved for a short time. The results obtained 

 with this subject are the most comprehensive of any secured thus far; 

 when combined with those of the previous year they will, it is hoped, 



