240 CARNEGIE INSTITUTION OF WASHINGTON. 



COOPERATING AND VISITING INVESTIGATORS. 



As in previous years, Professor Elliott P. Joslin has cooperated in the 

 research on severe diabetes in the respiration laboratory at the New 

 England Deaconess Hospital. The equipment of a clinical laboratory 

 in the hospital gives complete facilities for coordinated research on both 

 the respiratory and urinary products in diabetes. 



Dr. Fritz B. Talbot has continued his cooperation in the study of 

 the metabolism of normal infants at the Directory for Wet Nurses of the 

 Boston Infants' Hospital and will also cooperate in the investigation at 

 another Boston institution in which the metabolism of normal children 

 from 2 to 6 years of age will be studied. 



Dr. J. Arthur Harris, of the Station for Experimental Evolution, 

 Cold Spring Harbor, has supervised a statistical elaboration of pub- 

 hshed and unpublished data obtained in the Nutrition Laboratory, 

 with the special purpose of determining physiological constants for 

 normal individuals. 



Numerous investigators have spent short periods for conference or 

 experimental observation at the Laboratory; among others may be 

 mentioned Dr. Paul Roth, of Battle Creek, Michigan; Dr. Roy G. 

 Pearce, of Lakeside Hospital, Cleveland, Ohio; and Dr. Addison Gulick, 

 of the University of Missouri. 



INVESTIGATIONS IN PROGRESS. 

 METABOLISM DURING MUSCULAR WORK. 



The study of the metabolism of man during walking, which was 

 begun by Dr. Carl Tigerstedt and Dr. Hans Murschhauser in 1914 and 

 since continued by Dr. H. M. Smith, was designed to include both the 

 indirect and direct methods of heat measurement for horizontal and 

 grade walking. That part of the study dealing with the indirect 

 measurement has been completed and the work of compiling the results 

 secured during grade walking has been continued, although subject to 

 some interruption. It is hoped to have this part of the work completed 

 by the end of the present year. 



PreUminary to starting the series of tests for direct measurement of 

 the heat evolved during walking, the large respiration calorimeter 

 designed for such experiments has been thoroughly examined and the 

 usual tests for tightness and electrical and alcohol check tests have 

 been made with satisfactory results. 



The treadmill used in the walking experiments, which will likewise 

 be used in the respiration chamber, has also been carefully inspected 

 and tested and some changes made to adapt it for the work in view. 



For the series of experiments on heat-production during walking it 

 has been found necessary to reconstruct the absorber table connected 

 with the large calorimeter so as to permit much more thorough ventila- 



