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CARNEGIE INSTITUTION OF WASHINGTON. 



parison of the tests and controls in this generation gives, as a whole, the same 

 sort of results as given by the rats in the next generation, namely, the test rats, 

 on the average, do worse than the controls. But instead of being greater, the 

 difference between the tests and controls (although one generation nearer to 

 the actual alcohol) is less marked. 



"There are about 100 rats in this generation, from four strains. Three of 

 these strains show a clear preponderance of averages favoring the controls 

 when the trials on each day of training are taken separately; the fourth strain 

 does not show any difference at all between the two groups. The averages 

 for time obtained, when all strains are put together, are shown in table 3; the 

 differences on each day are plus (the tests taking moro time), with the single 



Table 3. — Averages of time elapsed in reaching center of jnaze per day of 4^ children (tests) of 

 alcoholic parents compared with 43 controls on each day of training on the maze. 



exception of the third day. However, on none of the first three days are the 

 differences great enough to have any significance. For the most part, the 

 differences on the other days do show that the tests are significantly slower in 

 running the maze than are the controls. The criterion of perfect trials gives 

 similar results. The controls made more perfect trials; they required fewer 

 trials before making the first one; and the}'' spent less time in running them. 



Table 4. — Comparison of children in respect to perfect trials. 



It is too soon to make final comparisons between the generations, but the 

 results so far seem to show that two of the three strains that are represented in 

 both generations bear the same relative positions in each generation. Strain 

 C is a fast one in both generations; strain L a slower one; strain A, however, is 

 different in the two generations, being slower in the later generation. This 

 difference in strain A may very possibly be associated with the appearance of a 

 sort of inherited hydrocephalous (pig-headed) condition in the later generation. 



