240 



CRILE-FRICKE— APPLICATION OF BIOPHYSICAL 



roles played in these temperature changes by alterations in the 

 blood circulation, in the blood temperature, and in the metabolism 

 of the organ. 



Inhalation anesthesia. — Ether in its first stages frequently pro- 

 duced an increase in the temperature of the brain. As the depth of 

 the anesthesia was increased the temperature fell. Fig. i shows the 



Fig. I. Effect of the administration of small amounts of ether on the tempera- 

 ture of the brain and of the liver. 



effect of the successive administration of small amounts of ether, the 

 intervals being long enough to allow the animal to become nearly 

 conscious between the doses. 



Nitrons-oxide as compared with ether showed a less marked 

 change in the temperature and fewer fluctuations, thus giving a more 

 stabiHzed curve (Fig. 2). 



Chloroform showed an initial rise in temperature corresponding 

 to that produced by ether. When full anesthesia was established the 

 temperature fell. 



Adrenalin: A number of observations have been made of the 

 effect of the intravenous injection of adrenalin upon the temperature 



