RESEARCH TO MEDICAL PROBLEMS. 243 



The uniform dosage employed throughout was the same as that used 

 in previous researches, viz., 0.4 c.c. per kg. of i : 1000 adrenalin 

 chloride (P. D. & Co.). 



In every case, the brain showed a very characteristic rise in tem- 

 perature, the temperature increase continuing for from ten to fifteen 

 minutes and amounting, on an average, to about 0.7° C. The other 

 organs usually show an effect just opposite to that in the brain, the 

 minimum temperature, however, usually occurring a few minutes 

 later than the corresponding maximum for the brain. 



In several cases the temperature of the spleen and of the intestine 

 fell markedly, in some cases as much as two degrees or more (Fig. 4). 



In all the above experiments the thermocouple was inserted in the 

 gray matter of the brain and in every case a rise in temperature was 

 noted. It was found, however, that when the thermocouple was 

 placed in the white matter, no change in temperature occurred after 

 the injection of adrenalin. 



Amyl Nitrite: The inhalation of amyl nitrite produced a marked 

 rise of 1.1° C. in the brain temperature, the liver showing no de- 

 cided effect, excepting a slight, continuous decrease in temperature. 



Electrolytes: The action of sodium and calcium chlorides has an 

 important theoretical interest. Fig. 6 shows the effects of the in- 

 jection of these salts upon the temperature of the brain. The well- 

 known antagonistic relation existing between sodium chloride and 

 calcium chloride is strikingly illustrated. The doses given were 2 

 c.c. of a saturated solution — 36 per cent. — of sodium chloride and 

 I c.c. of a 10 per cent, solution of calcium chloride. 



Sodium Cyanide: The action of a strong poison was shown by 

 various injections of sodium cyanide. The injection of 0.00 1 N solu- 

 tion caused a slight rise of temperature, corresponding to the stage of 

 excitement. The injection of o.oi A^ solution produced a state of 

 depression, while an injection of o.i A^ solution caused an immediate 

 drop in temperature followed by a marked rise ; during a period in 

 which violent tremors and convulsions were occurring. During 

 these convulsions the temperature fluctuated over a range of 0.1° C. 

 The result of the injection of still stronger doses was an immediate, 

 rapid decrease in the temperature of the brain followed in a few 

 minutes by death. 



