X CONTENTS 



34. The Ribonucleic Acids of Viruses by Heinz Schuster 



I. Introduction 245 



II. Viruses Which Contain Ribonucleic Acid; General Remarks 246 



III. The Ribonucleic Acids of Plant Viruses 251 



IV. The Ribonucleic Acids of Animal Viruses 293 



35. Biosynthesis of Purine Nucleotides by John M. Buchanan 



I. Introduction 304 



II. Precursors of the Purines 304 



III. Enzymic Reactions of Inosinic Acid Synthesis de Novo 306 



IV. Enzymic Synthesis of Formyltetrahydrofolic Acid Compounds 318 



V. Synthesis of Adenylic Acid from Inosinic Acid 319 



VI. Synthesis of Guanylic Acid from Inosinic Acid 320 



VII. Summary 321 



36. Biosynthesis of Pyrimidine Nucleotides by George W. Crosbie 



I. Introduction 323 



II. Biosynthesis of Uridine Nucleotides 323 



III. Biosynthesis of Cytidine and Deoxycytidine Nucleotides 332 



IV. Biosynthesis of Thymidine Nucleotides 337 



V. Alternative Pathways of Pyrimidine Nucleotide Synthesis 347 



37. The Relationship of Nucleic Acid and Protein Synthesis as Revealed by 

 Studies in Cell-Free Systems by Mahlon B. Hoagland 



I. Introduction 349 



II. Participation of Cellular Nucleic Acid-Containing Fractions in Protein 



Synthesis 352 



III. Theoretical Considerations 398 



38. Biosynthesis of Proteins in Intact Bacterial Cells by F. Gros 



I. Introduction 409 



II. Organization of the Bacterial Cell 410 



III. Synthesis of Macromolecular Components during Normal Bacterial 

 Growth 419 



IV. Uncoupled Synthesis of Macromolecules in Bacteria 430 



V. Protein Synthesis After Selective Destruction or Removal of a Nucleic 



Acid 440 



VI. General Discussion 447 



VII. Addendum 450 



39. AgentsWhich Influence Nucleic Acid Metabolism by R. E. Handschumacher 

 and A. D. Welch 



I. Introduction 453 



II. Compounds Which Interfere with the Formation of Folic Acid-Derived 



Coenzymes 456 



III. Compounds Which Interfere with Amination Reactions in Purine and Py- 

 rimidine Synthesis 471 



IV. Structural Analogs of Purines and Their Metabolic Activity 477 



V. Structural Analogs of Pyrimidines and Their Effects on Nucleic Acid Me- 

 tabolism 498 



VI. Other Agents Which Influence Nucleic Acid Metabolism 519 



VII. Concluding Remarks 525 



