574 



SUBJECT INDEX 



Antibiotics 



nucleic acid antimetabolites and, 496- 



497 

 ribonucleic acid synthesis and, 152, 

 154-155 

 Antimetabolites, 453-526 

 Antrycide, nucleic acids and, 523 

 Apurinic acid, photolysis and, 87 

 Ascites tumor cells, protein synthesis 



and, 365-366, 370, 387 

 Aspartic acid, incorporation of, 305, 307, 



309 

 Autoradiography, DNA synthesis and, 



530-532, 540 

 Azaquanine 

 deoxyribonucleic acid incorporation 



and, 489-490, 492 

 enzyme induction and, 434 

 inactivation of, 490-491 

 mechanism of action and, 488-493 

 microbial studies and, 490 

 protein synthesis and, 492 

 ribonucleic acid incorporation and, 



489, 490, 492-493 

 structure of, 488 

 tobacco mosaic virus and, 276 

 Azapyrimidines, 512-516 

 Azaserine 



antagonists of, 474, 476 

 chemotherapeutic studies and, 475-476 

 E. coli, metabolism and, 474 

 enzyme inhibition by, 313-314, 474-475 

 formylglycinamide ribonucleotide and, 



473-474 

 leukemia and, 477 

 mechanism of action and, 473-476 

 structure of, 473 

 Azathymidine 

 biological properties, 515-516 

 derivatives of, 516 

 synthesis of, 512 

 6-Azathymine 



biological properties of, 515-516 

 mechanism of action of, 516 

 Azauracil 

 pyrimidine metabolism and, 512-515 

 synthesis of, 512 

 Azauridine, biological properties, 513- 

 515 



B 



Bacteria, deoxyribonucleic acid compo- 

 sition of, 166-172 



actinomycetes, 172-173 



cocci, 170-172 



enterobacteriaceae, 168, 171 



gram-negative bacilli, 167, 170-171 



gram-positive bacilli, 169, 171 



mycobacteria, 172-173 



strain differences and, 172 

 Bacterial cells 



amino acid activation and, 412-416 



cell wall of, 418-419 



cytoplasmic membrane of, 418-419 



deoxyribonucleic acid, of, 417-418 



enzyme synthesis and, 432-436 



metabolic pool of, 410-412 

 amino acids and, 410 

 nucleic acids and, 412 

 peptides and, 411 



ribonucleic acid-amino acid pool of, 

 413-414 



ribonucleo protein, state of, 415, 416- 

 417 



soluble ribonucleic acid and, 412-416 

 Bacterial viruses, see Bacteriophage 

 Bacteria, ribonucleic acid composition 

 of, 175-181 



gram-negative, 176-177 



gram-positive, 178 

 Bacteriophage 



action spectrum for, 91 



minute, 242-243 



nucleic acids of, 187-244, see also Nu- 

 cleic acids 



phosphorus transfer and, 207 



thermal reactivation and, 100 

 Bacteriophage, T5 



composition of, 229 



deoxyribonucleic acid, host and, 229- 

 230 



deoxyribonucleic acid synthesis and, 

 230-231 



infection with, 229-231 

 Bacteriophage, temperate 



deoxyribonucleic acid of, 238-239 



lysogenic state of, 235-237 



lysogenization, biochemistry of, 237- 

 239 



