578 



SUBJECT INDEX 



Far ultraviolet spectra, 50-51 

 Flash-spectrosopy technique, 43-44 

 Fluorescence, 42 

 Fluorocytidine, 506 

 Fluorodeoxyuridine 



deoxyribonucleic acid and, 503 



thymineless death and, 503 

 5-Fluoro-2'-deoxyuridylic acid, 501 

 5-Fluoroortic acid 



mechanism of action, 500, 505 



metabolism of, 500 



structure of, 499 

 5-Fluorouracil 



catabolism of, 505 

 deoxyribonucleic acid synthesis and, 

 499-501, 503-504 



enzyme studies and, 503-504 



inhibition action of, 499-505 



metabolic effects of, 435-436 



metabolism of, 501-505 



ribonucleic acid and, 500-502 



structure of, 499 



synthesis, chemical, 498-499 



tobacco mosaic virus and, 277-278 

 5-Fluorouracil-/3-D-ribofuranoside 



biological properties of, 502 



synthesis of, 502 

 Fluoruridine, 501-502, 504 

 Folic acid metabolism 



enzymes of, 458 



formate metabolism and, 460 



S. faecalis and, 4(55-466 

 Folic acid reductase, 458-459 



activity of, 466 



inhibitors of, 458 

 Folinic acid, amethopterin and, 458 

 5 - Formamido - 4 - imidazolecarboxamide 

 ribonucleotide 



biosynthesis of, 316-317 

 Formate, incorporation of, 305-306, 462, 



492, 500, 503 

 Formylglycinamidine ribonucleotide 



biosynthesis of, 312-313 



nucleic acid metabolism and, 473 

 Formyltetrahydrofolic acid compounds, 



enzymic S3 r nthesis of, 318-319 

 Free radicals 



electron transport system and, 44 



isolated enzyme systems and, 45 

 lyophilized tissue and, 44-45 

 Fungi 

 deoxyribonucleic acid composition of, 



173-174 

 ribonucleic acid composition of, 179 



/3-Galactosidase, synthesis of, 420-421, 



431, 432, 434, 442, 446 

 Glutamine 



amino-donor and, 472 

 analogs of, 471-473, 477 

 incorporation of, 305, 307-308, 310 

 Glycinamide ribonucleotide, biosyn- 

 thesis of, 309-311 

 Glycinamide ribonucleotide transformyl- 



ase, 312-313 

 Glycine, incorporation of, 305, 307, 309, 

 311, 338-339 

 azaguanine inhibition and, 492 

 radiation and, 533 

 Guanase, 490-491 

 Guanine 

 antagonists of, 488-489, 493 

 ultraviolet irradiation and, 64 

 ( iuanosine-5'-diphosphate, polynucleo- 

 tide phosphorylase and, 131-132 

 Guanosine triphosphate, protein synthe- 

 sis and, 364, 366-367, 370, 388-392 

 Guanylic acid 

 biosynthesis of, 308 

 enzymes of, 320-321 

 inosinic acid and, 320-321 



H 



Halogenated pyrimidines, see also Fluor- 

 ouracil 

 synthesis of, 506 

 HeLa cells 



radiation and, 545 

 reproduction of, 507 

 Hemoglobin, amino acid incorporation 



and, 368-369 

 Histidine catabolism, folic acid, 462 

 Hydrodynamical methods, 3-6, 30, see 

 also molecular weight determination 

 monodispersed solution, 3-4 

 polydispersed solutions, 4-0 

 4-Hydroxy-l,3-dimethylhydrouracil, 71 



