SUBJECT INDEX 



579 



5-Hydroxymethylcytosine, deoxyribonu- 

 cleic acid and, 201, 205-207 

 5-Hydroxymethyl deoxycitidine-5'-phos- 



phate, biosynthesis of, 336-337 

 5-Hydroxymethyldeoxycytidylic kinase, 



213 

 N-Hydroxymethyltetrahydrofolic acid, 



purine biosynthesis and, 339 

 5-Hydroxypyrimidine, 511 

 Hyperchromicity 

 cause of, 57 



deoxyribonucleic acid and, 55-56 

 polymer interaction and, 55-56 

 proteins and, 59 

 urea effect, 55-56 

 Hypoxanthine 

 biosynthesis of, 305-306 

 6-mercaptopurine and, 479 

 ultraviolet irradiation and, 64-65 



I 



Infectious ribonucleic acid, tobacco mo- 

 saic virus and, 81-82, 84 

 Infrared spectroscopy, aqueous solution, 



51-52 

 Inosinic acid synthesis, de novo, 

 5-amino-4-imidazole carboxylic acid 



ribonucleotide and, 314-315 

 5-aminoimidazole ribonucleotide and, 



314 

 5-formamido-4-imidazolecarboxamide 



ribonucleotide and, 316-318 

 formylglycinamide ribonucleotide and, 



311-312 

 formylglycinamidine ribonucleotide 



and, 313 

 glycinamide ribonucleotide and, 311 

 mechanism of, 321-322 

 5-phosphoribosylamine and, 310-311 

 precursors of, 305, 307 

 reactions for, 307 

 ribose-5-phosphate and, 309 

 Inosinic acid transformylase, 462 

 Inosinicase, 316-317 

 Inosinic pyrophosphorylase, 481 

 Internucleotide bonds, synthesis of 

 activated nucleosides and, 110-111 

 direct activation of mononucleotides 



and, 112-113 

 mixed anhydrides and, 111-112 



phosphorochloridates and, 111-112 



phosphorylating agents in, 109-110 



Iododeoxyuridine, nucleic acids and, 507- 



509 

 Iodouracil deoxy ribonucleotide, 508 

 Iodouracil, nucleic acids and, 506, 508 



Leukemia, 457 



folic acid antagonists, 463 



folic acid-reductase and, 466 



glutamine analogs and, 477 



granulocytic, 464 



L-1210 strain of mice, 466 



lymphoblastic, 457 



6-mercaptopurine and, 478 



myelocytic, 457 



thioguanine, as drug for, 484 



in vitro studies, 464 

 Light scattering, 7-15, 19-30 



dispersions, reproducibility of, 23-28 



large angle, 28-30 



small angle, 21-23 

 Liver, radiation effects, 536, 542 

 Lymphocytic choriomeningitis Virus, 467 

 Lysine-C 14 , incorporation, 536 



M 



Mandelkern equation, 33 

 6-Mercaptopurine 



anabolism of, 480-481 



antagonists of, 479 



antitumor activity of, 478 



catabolism of, 480-481 



incorporation in nucleic acids, 481 



mechanism of action and, 479-483 



microbial experiments and, 478-480, 

 482-483 



resistance to and, 481 



structure of, 478 



xanthine oxidase and, 480 

 Mercaptopurine ribonucleoside, 480-482 

 5-Mercaptopyrimidine, 511 

 Methionine activating enzyme, 383-384 

 Methionine, thymine and, 338 

 6-Methylaminopurine, 156-157 

 Methylcytosine 



deoxyribonucleic acid and, 156 



reversible photolysis and, 76 



ribonucleic acid and, 160 



