CONTENTS 



Dedication v 



Preface vii 



Introduction xv 



Conventions xix 



Symbols xix 



CHAPTER 1 



Malonate 1 



Early Historical Development 1 



Chemical Properties 3 



Inhibition of Succinate Dehydrogenase 15 



Inhibition of Succinate Oxidation in Cellular Preparations .... 50 



Inhibitions of Enzymes Other Than Succinate Dehydrogenase ... 58 



Effects of Malonate on the Operation of the Tricarboxylic Acid Cycle . 69 



Accumulation of Succinate during Malonate Inhibition 90 



Accumulation of Cycle Substrates Other than Succinate 104 



Antagonism of Malonate Inhibition with Fumarate 112 



Specificity of Malonate Inhibition in the Cycle 117 



Effects of Malonate on Oxidative Phosphorylation 118 



Effects of Malonate on Glucose Metabolism 122 



Effects of Malonate on Lipid Metabolism 135 



Effects of Malonate on Amino Acid and Protein Metabolism .... 151 



Effects of Malonate on Porphyrin Synthesis 158 



Effects of Malonate on Miscellaneous Metabolic Pathways 163 



Effects of Malonate on the Endogenous Respiration 166 



Permeability of Cells to Malonate 186 



Growth, Development, and Differentiation 192 



Cellular and Tissue Function 202 



Effects of Malonate in the Whole Animal 217 



Effects of Malonate on Bacterial Infections 221 



Metabolism of Malonate 224 



Inhibitors Structurally Related to Malonate 235 



XI 



