xii CONTENTS 



CHAPTER 2 



Analogs of Enzyme Reaction Components 245 



Terminology 246 



Possible Sites and Mechanisms of Inhibition 246 



Kinetics of Analog Inhibition 248 



Means of Expressing Results 252 



Important Types of Molecular Alteration Producing Inhibiting Analogs . 255 



Development of the Concept of Inhibition by Analogs 259 



Analog Inhibition of Membrane Transport 261 



Analogs Which Are Isomers of Substrates 268 



Fumarase 274 



Inhibition of Xanthine Oxidase by Purine Analogs and Pteridines . . 279 



Choline Oxidase 290 



Inhibition of Nitrogen Fixation by Other Gases 291 



Phenol Oxidases 296 



Tyrosine Metabolism 302 



Tryptophan Metabolism 321 



Glutamate Metabolism 327 



Arginase 335 



L-Amino Acid Oxidases 338 



D-Amino Acid Oxidase 340 



Analog Inhibition of the Metabolism of Various Amino Acids .... 350 



Diamine Oxidase (Histaminase) 360 



Carboxypeptidase, Aminopeptidases, and Dipeptidases 365 



Chymotrypsin and Other Proteolytic Enzymes 368 



Hexokinases 376 



Effects of 2-Deoxy-D-Glucose on Carbohydrate Metabolism .... 386 



Effects of 6-Deoxy-6-Fluoro-D-Glucose on Metabolism 403 



Various Analog Inhibitors of Carbohydrate Metabolism 405 



Glycosidases 415 



Pyruvate Metabolism 429 



Lactate Metabolism 432 



Phosphatases 439 



Sulfatases 443 



Adenosinetriphosphatases and Transphosphorylases 444 



Hydroxysteroid Dehydrogenases 447 



Nitrite and Sulfite Metabolism 450 



Simple Ion Antagonisms 452 



Inhibition by Macroions 453 



Inhibitions by Nucleotides and Related Substances 465 



Inhibitions by Coenzyme Analogs 482 



Analogs of Nicotinamide and the Pyridine Nucleotides 484 



Analogs of Thiamine 514 



Analogs of Riboflavin and FAD 534 



Analogs of Pyridoxal 561 



Analogs of Pteroylglutamate (Folate) 579 



