CONTENTS Xni 



Analogs of Other Vitamins, Coenzymes, and Their Components . . . 586 



Miscellaneous Analog Inhibitions 590 



CHAPTER 3 



Dehydroacetate 617 



Chemical Properties 618 



Inhibition of Enzymes 620 



Effects on Respiration and Glycolysis 623 



Effects on Tissue Functions 624 



Effects on the Whole Animal 627 



Distribution and Metabolism 629 



Antimicrobial Activity 631 



CHAPTER 4 



Sulfhydryl Reagents 635 



Role of SH Groups in Metabolism and Function 636 



Chemical Properties of SH Groups 637 



Types of SH Reaction Important in Inhibition 642 



Factors Determining the Reactivities of SH Groups 643 



Interpretation of Inhibitions by SH Reagents 647 



Protection and Inhibition Reversal by Thiols 650 



General Considerations of the Uses of SH Reagents 651 



CHAPTER 5 



Oxidants 655 



Disulfides 661 



Porphyrexide and Porphyrindin 664 



Ferricyanide 670 



Iodine 678 



Peroxides 690 



Tetrathionate 696 



CHAPTER 6 



o-lodosobenzoate 701 



Chemistry 701 



Reaction with Protein SH Groups 703 



Inhibition of Enzymes . 704 



Inhibition of Metabolism 721 



Effects on Animal Tissue Functions 723 



Effects in Whole Animals 724 



Effects on Sea Urchin Egg Development 726 



Effects on Bacteria and Viruses 727 



