102 



1. MALONATE 



Table 1-18 



Tissue Succinate and Malonate Concentrations Following Injections of 



Malonate in Rats " 



" The figures are in /<equivalents/g wet weight of tissue. Malonate was injected 

 subcutaneously at a dosage of 12 millimoles/kg, and after 1 hr a similar amount was 

 again injected; 1 hr following the last injection the animals were sacrificed. (From 

 Busch and Potter, 1952 b.) 



linear relationship may not be followed. These ratios indicate the amount 

 of succinate formed per unit concentration of malonate and do not relate 

 directly to the degree of inhibition of succinate oxidase but more to the 

 ability of the tissue to form succinate in the presence of the inhibition. 

 As discussed previously, for the same degree of block, succinate will be form- 

 ed at greatly different rates in different tissues, depending on the succin- 

 ate-forming substrates available and the activity of the pathways leading 

 to succinate. The concentrations of malonate in the tissues vary greatly 

 and this must be a reflection of the differing permeabilities of the tissues to 

 malonate. It may be noted that the concentration in the brain is quite low, 



