134 



1. MALONATE 



an increase in cycle activity since the concentration of malonate was 100 

 mM and more than the cycle might be inhibited. 



Effects on Resting and Stimulated Glucose Metabolism in Brain 



The effects of malonate on a tissue may depend on the activity of the 

 tissue as well as the age. Stimulation of a tissue such as brain alters the 

 metabolic pattern and this is exhibited in altered responses to inhibitors. 

 The results obtained by Heald (1953) on guinea pig cerebral cortex slices 

 are shown in Fig. 1-14. The resting respiration and aerobic glycolysis are 



( Malonote ! 



10 100 

 mM 



Fig. 1-14. Effects of malonate on guinea pig brain 

 slices with glucose as the substrate. Electrical stimula- 

 tion through grids. The respiration and aerobic glycol- 

 ysis in //moles/g wet weight/hr. (From Heald, 1953.) 



