290 



2. ANALOGS OF ENZYME REACTION COMPONENTS 



CHOLINE OXIDASE 



The inhibitions of liver choline oxidase reported by Wells (1954) (Table 

 2-3) recall the interferences exerted by these and similar analogs on cho- 

 linesterase and tissue acetylcholine receptor groups. It would appear that 

 a certain critical distance between the N+ group and the terminal CH2OH 



Table 2-3 

 Inhibition of Rat Liver Choline Oxidase by Choline Analogs" 



"Experiments done with rat liver homogenates. Choline and all analogs at 37.5 mM. The 

 rates of oxidation are given relative to that for choline (100). (From Wells, 1954.) 



