312 2. ANALOGS OF ENZYME REACTION COMPONENTS 



Table 2-11 (continued) 



Inhibitor 



Concen- 

 tration 

 (mA'i) 



% 

 Inhibition 



Relative 



- AF of 



binding 



(kcal/mole) 



d-Hydroxy- 

 Unsubstituted 



Phenylacetates 



3, 4-Dihydroxy- 

 2, 5-Dihydroxy- 

 3, 4-Dimethoxy- 

 3 -Hydroxy - 

 Unsubstituted 



CH,— COO" 



Phenylglycines 



3, 4-Dihydroxy- 

 3-Hydroxy- 

 4-Hydroxy- 

 Unsubstituted 



=\ NH, 



CH 

 \ 

 COO 



3.24 



Phenylpyruvates 



3, 4-Dihydroxy- 



3-Hydroxy- 



4-Hydroxy- 



2, 5-Dihydroxy- 



Unsubstituted 



CH5— CO— COO' 



0.2 



1 



2 



2 



2 



60 

 72 

 60 

 60 

 60 



5.92 

 5.26 

 4.50 

 4.50 

 4.50 



Benzoates (\ n — - COO" 



2-Hydroxy-3, 5-diiodo- 

 2-Hydroxy-3, 5-dibromo- 

 3, 5-Dibromo- 

 3,4, 5-Trihydroxy- 

 3-Hydroxy-4, 6-dibromo- 

 2 -Hydroxy- 5-amino- 

 2-Hydroxy-4-nitro- 



