330 2. ANALOGS OF ENZYME REACTION COMPONENTS 



relative binding energies have been calculated. Inhibitors were classed as 

 competitive if the interaction constant a is greater than 10; trimesate and 

 D-glutamate are only partially competitive, with a = 1.7. It was postulated 



CCXD' 

 ^O. ^COO" 



COO 



Furcate Isophthalate 



COO 



COO' 



OOC \^ COO 



Trimesate Indole-3-carboxylate 



that the enzyme contains two cationic groups at a separation optimal for 

 interaction with the carboxylate groups of glutamate, glutarate, and iso- 

 phthalate. The effects of some other inhibitors for which the ^/s were 

 not calculated are shown in the following tabulation; most of these are 



