344 



2. ANALOGS OF ENZYME REACTION COMPONENTS 

 Table 2-17 (continued) 



Inhibitor (3 mM) 



Nicotinate 



Structure 



N- 

 // W 



COO 



Inhibition 



65 



Nicotinamide 



N — V 



CONH, 



2-Furoate 



O^ ^COO 



W 



100 



Indol e - 2 - ca rbox yl ate 



H 



N^ COO' 



100 



Benzoate 



/»-Methoxybenzoate 

 o - Methoxybenzoate 

 /J-Carboxybenzoate 

 o - Carboxybenzoate 

 Hz-Carboxyben^oate 



Cyclohexanecarboxylate 



€y 



COO 



( V-coo' 



100 



100 



67 



74 



3 



20 



53* 



Hydroquinone 



Tribromophenol 



/>-Aminophenol 



Triiodophenol 



Catechol 



3, 5-Dihydroxyphenol 



2, 3-Dihydroxyphenol 



Resorcinol 



73 



40 



30 



19 



19 



5 











" The substrate is o-alanine at 6.25 mM and the pH 8.3. The inhibitions marked 

 with an asterisk are at least partially due to contamination with the unsaturated 

 compounds. (Data from Frisell (7 (v/., 1956.) 



