364 



2. ANALOGS OF ENZYME KEACTION COMPONENTS 



Fig. 2-8. Inhibition of pig kidney diamine oxidase with cadav- 

 erine (5 niM) as the substrate and all the inhibitors at 1 mM. 

 (From Blaschko et ah, 1951.) 

 NH, 



(A) Monamidines 



H3C — (CHa)^ C 



NH 



(B) Diamidines 



H,N 



NH, 





(C) Dibenzamidines 



(D) Diguanidines 



H2N 

 HN 

 H,N 



0-(CH2)„-0— ( 



NH, 



NH, 



W 

 NH 



C-NH-(CH2)— HN-C^ 

 HN ^NH 



(E) Diisothioureas 



H,N 



NH, 



C-S- CH,L— S— C 



// \\ 



HN NH 



