366 



2. ANALOGS OF ENZYME REACTION COMPONENTS 



A. 



Acyl-L-phenyl- 

 alanine (substrate) 



(3"'-^l 



L- Phenylalanine 



/^ X NH3 Vc 



r hV 



Benzoate 



\^ y CHj 



D- Phenylalanine 



Ql 



Phenylacetate 



Propionate 



Q- 



3 - Pheny Ipr opionat e 

 (hydrocinnamate) 



Valerate 



y- Pheny Ibuty rate 3-Indoleacetate 



Fig. 2-9. Possible orientations of substrate and inhibitors at the active center of 

 carboxypeptidase. (A) is peptidatic site, (B) is cationic site, and (C) is electrokinetic 

 site. The molecular configurations are only approximate. 



