CHYMOTRYPSIN AND OTHER PROTEOLYTIC ENZYMES 



371 



Table 2-20 

 Competitive Inhibition of q-Chymoteypsin by Analogs " 



Inhibitor 



Apparent K^ Relative — AF oi binding 

 (mil/) (kcal/mole) 



Tryptophan series 

 L-Tryptophanamide 

 D-Tryptophanamide 

 Acetyl-D-tryptophanamide 

 Trifluoroacetyl-D-tryptophanamide 

 Acetyl-L-tryptophanmethylamide 

 Acetyl-D-tryptophanmethylamide 

 Benzoyl-D-tryptophanamide 

 Nicotinyl-D-tryptophanamide 

 p-Methoxybenzoyl-D-tryptophanamide 

 Acetyl-L - tryptophanate 

 Acetyl-D -tryptophanate 

 Acetyl-D-tryptophan isopropylester 

 Tryptamine 

 Acetyltryptamine 

 Trifluoroacetyltryptamine 

 Indole 



Indoleacetate 

 Indolepropionate 

 Indolebutyrate 

 Indolepropionaraide 



Tyrosine series 



Acetyl-D-tyrosinamide 



Trifluoroacetyl-D-tyrosinamide 



Chloroacetyl-D-tyrosinamide 



Nicotinyl-D-tyrosinamide 



Acetyl-L-tyrosinemethylamide 



Formyl-L-tyrosinemethylamide 



Nicotinyl-L-tyrosinemethylamide 



Benzoyl-L-tyrosinemethylamide 



Acetyl-L-t>Tosinate 



Fluoroacetyl-L-tyrosinate 



Chloroacetyl-L-tyrosinate 



Acetyl-D-tyrosine ethyl ester 



Nicotinyl-D-t>Tosine ethylester 



D-Tyrosinehydroxamide 



Acetyl-D-tyrosinehydroxamide 



