ANALOGS OF PYRIDOXAL 



571 



Table 2-37 

 Effects of Pyridoxine Analogs on Rat Brain Gltjtamate Decarboxylase ° 



° From Rosen et al. (1960). 



'' The analogs were injected intraperitoneally for 7 days, except for 3-deoxyp>Ti- 

 doxol, which convulsed the animals after a single dose. 



glutaminase is also reduced by deoxypyridoxol at 21 days, at which time 

 dietary deficiency produces no change (Beaton and Goodwin, 1955). 



It is impossible to evaluate the importance of these changes in enzyme 

 levels for the toxic effects of deoxypyridoxol. The toxic effects are mani- 

 fested principally in the central nervous system, skin, and hematopoietic 

 system, and no enzyme determinations during deoxypyridoxol treatment 

 have been reported in any of these tissues, except for brain glutamate de- 

 carboxylase. There is no reason to attribute the toxic effects to reduction 

 of transaminase rather than to the possible reduction of many other en- 

 zymes dependent on pyridoxal-P, most of which have never been examined 

 in this connection. It is more likely that the growth inhibition observed 



