580 



2. ANALOGS OF ENZYME REACTION COMPONENTS 



H,N 



-NH 



v\ // 



COO 



I 



CH, 



I " 

 CHo 



I "" 

 CH— COO" 



I 



CONH 



Folate 



H,N 



OH CHO 



5-Formyltetrahydrofolate 

 (folinate, citrovorum factor) 



H,N^ /N. /N^ ^CH, 



OH 



7-Methylfolate 



H,Nv. M^ M 



H,N 



NH, 



Amethopterin 

 (methotrexate) 



Pyrimethamine 

 (Daraprim) 



2, 4, 7 Triamino-6- 

 o-methylphenylpteridine 



