MISCELLANEOUS ANALOG INHIBITIONS 



605 



Table 2-39 

 Analog Inhibition of Dehydroshikimate Reductase" 



Analog 



Structure 



Relative - AF 



of binding 



(kcal/mole) 



Vanillin 



CH3O 



HO— (\ V-CHO 



5.72 



(Shikimate) 



Gallate 



HO 

 HO— ( />— COO' 

 HO 

 HO 



HO 



COO 



HO 



(5.29)' 



4.85 



/»-Hydroxybenzoate 



^0—{\ ,)— COO" 



4.13 



Protocatechuate 



HO 



HO— <x /)— COO 



4.12 



Catechol 



HO 



HO 



3.86 



Guaiacol 



CH3O 



2.78 



