SUBJECT INDEX 



1185 



o-iodosobenzoate, 710, 718-719 



variation of inhibition with subs- 

 trates, 718-721 

 malonate, 62 

 mercurials, 719, 860 

 porphyrexide, 668 

 Lipids, see also Fatty acids. Phospholipids, 

 Sterols 



biosynthesis of, mercurials, 886-887 

 metabolism of, see also Lipogenesis 

 malonate, 135-151 

 propionate, 613-614 

 Lipoamide dehydrogenase, see NADH: 



lipoamide oxidoreductase 

 Lipoate, 



analogs of, 590 



acetyllipoate biosynthesis, 590 

 acyl transfer, 590 

 phosphotransacetylase, 590 

 pyruvate decarboxylation, 590 

 pyruvate oxidation, 590 

 mercurials, complexes with, 750-751 

 mercurial toxicity, antidote for, 751 

 pyruvate oxidase, antagonism of mer- 

 curial inhibition, 751 

 Lipogenesis, 2-deoxyglucose, 399 

 Lipoprotein lipase, macroions, 463 

 Lithium, phosphotransacetylase, 452 

 Liver, 



acetate oxidation, malonate, 78 

 acetate utihzation, propionate, 613 

 acetoacetate accumulation, malonate, 

 138-144 



acetoacetate metabolism, malonate, 

 115, 139-140, 144 



ADP levels in, 2-deoxyglucose, 395 

 D-alanine oxidation, benzoate, 341 

 amino acid levels in, mercurials, 954 

 amino acid oxidation, kojic acid, 350 

 aminomalonate decarboxylation in, 239 

 arginine conversion from citrulline, ma- 

 lonate, 157-158 



aspartate oxidation, malonate, 152 

 ATP levels, 



aminopterin, 585 

 2-deoxyglucose, 395 

 malonate, 157-158 



Ca++ uptake by mitochondria, mercu- 

 rials, 909-910 



cholesterol metabolism, malonate, 150 

 citrate accumulation in vivo, malonate, 

 104 



citrate oxidation, trans-aconitate, 273 

 Cu++ uptake, mercurials, 910, 913 

 cycle intermediates concentrations in, 

 89 



damage by mercurials, 954 

 enzyme induction in, 8-azaguanine, 478 

 fatty acid biosynthesis, 



malonate, 148-149 



mercurials, 887 



propionate, 613 

 fatty acid dehydrogenation (anaerobic), 



malonate, 136-137 

 fatty acid oxidation, 



malonate, 114, 137, 141-143 

 folate metabolism, analogs, 582 

 glucose metabolism, 6-deoxy-6-fluoro- 

 glucose, 404 



glucuronide biosynthesis, analogs, 428 

 glutamate accumulation, malonate, 

 153-154 

 glutamate oxidation, 



galactoflavin, 544 



malonate, 152 



mercurials, 878 

 glycogen formation, D-glucosamine, 382 

 glycogen levels in, oxythiamine, 520 

 glycolysis, 



2-deoxyglucose, 383 



malonate, 126 

 glycolysis (aerobic), malonate, 128 

 GSH levels in, tetrathionate, 700 

 /5-hydroxybutyrate oxidation, 



galactoflavin, 544 



mercurials, 883 

 isocitrate oxidation, malonate, 79, 86 

 a-ketoglutarate oxidation, malonate, 80 

 K+ uptake by mitochondria, mercu- 

 rials, 909, 914 



lipogenesis, 2-deoxyglucose, 399 

 malate oxidation, malonate, 82 

 malonate, 



decarboxylation in, 233 



levels in vivo, 100, 102 



