SUBJECT INDEX 



1189 



electrocardiogram, 215 

 embryogenesis, 197-199 

 fatty acid oxidation, 114, 135-137 

 fatty acid biosynthesis, 146-149 

 flagellar activity, 203 

 fumarase, 275 



fumarate antagonism of inhibitions by, 

 112-117 



fumarate oxidation, 81 

 fungal growth, 195-196 

 gastric acid secretion, 187, 208 

 glucose metabolism, 122-135 

 glutamate decarboxylase, 328 

 glycerol metabolism, 164 

 glycolysis, 125-130 

 glyoxylate metabolism, 165 

 heart, 213-217 

 histamine release, 212-213 

 hydrogen bonding in, 4, 9 

 hydroxamic acid formation, 233 

 D-a-hydroxy acid dehydrogenase, 437 

 incorporation into lipids, 231 

 intercharge distance, 5-6 

 intestinal transport of, 207-208 

 ionic length and volume, 188 

 ionic species, pH effects, 9-10 

 ionization of, 5, 8-10 

 iron incorporation into heme, 163 

 isocitrate accumulation, 106 

 isocitrate oxidation, 79, 86 

 ketogenic activity, 138-144 

 a-ketoglute^rate oxidation, 72, 79-81, 

 83-86 



kynurenine: a-ketoglutarate transami- 

 nase, 608 



lactate formation, 126-128 

 lactate oxidation, 78 

 lethal doses, 201, 218 

 lipid metabolism, 135-151 

 malate oxidation, 81-82 

 metabolism of, 1-2, 105, 107, 138, 216, 

 224-235 



methylmalonate accumulation by, 145 

 mitochondrial swelling, 210-211 

 mitosis, 197-200 

 muscle, 212 

 nephrotoxicity, 219-221 



nerve conduction and potentials, 211- 



212 



occurrence of, 2, 224-226 



oxalacetate oxidation, 66-68, 82 



oxidative phosphorylation, 118-122 



partition ratios, 189 



pentose-P pathway, 130-132 



permeability to, 51, 56, 167, 186-192 



phagocytosis, 203, 223 



pH effects on inhibitions by, 181-182, 



189-192, 195-197 



phosphatase (acid), 442 



phospholipid metabolism, 151 



photosynthesis, 163-164 



plant growth, 196-197 



plasma K+ and Na+, 206 



plasma pH, 206 



porphyrin biosynthesis, 158-163 



propionate metabolism, 144-146 



protein biosynthesis, 155-157 



purification of, 3 



pyruvate oxidation, 73-77 



reduction of Ca++ and Mg++ concen- 

 trations, 13-14 



renal excretion of malate, 207 



renal transports, 203-207 



respiration (endogenous), 166-186 

 effect of functional activity, 183-184 

 effect of ions and buffer, 183 

 effect of tissue age, 182-183 

 factors determining inhibition, 166- 

 167, 180 



kinetics, 180-182 

 significance of inhibition, 186 



respiration (glucose), 123-125, 127, 133- 



135 



respiratory quotient, 184-185 



sequential inhibition with fluoroacetate, 



112 



specificity of inhibition, 58-59, 72, 117- 



118 



stability of, 3 



structure of, 4 



succinate accumulation by, 90-104 



succinate decarboxylation to propio- 

 nate, 165 



succinate dehydrogenase, 15-50 

 activation of, 45-46 



