1228 



SUBJECT INDEX 



3,5,3',5'-Tetraiodothyropropionate, thy- 

 roxine deiodinase, 602 

 Tetrathionate, 696-700, 

 blood GSH, 696 

 chemical properties, 697 

 conversion to thiosulfate, 699-700 

 cyanide poisoning, 696 

 cytochrome reduction by, 696 

 determination of protein methionine, 

 696 



enzyme inhibitions, 698-699 

 GSH levels in tissues, 700 

 nephrotoxicity, 700 

 oxidation of protein SH groups, 697- 

 698 



oxidation of thiols, 697-698 

 oxidation-reduction potential, 697 

 reaction with SH groups, 697 

 thromboangiitis obliterans, 696 

 toxicity, 700 

 Tetrolate, fatty acid biosynthesis, 614 

 Tetrolyl-CoA, fatty acid biosynthesis, 



613-614 

 Tetrose-diphosphate, see D-Threose-2,4- 



diphosphate 

 Thea pollen, malonate metabolism in, 228 

 Theobromine, NAD nucleosidase, 492 

 Theophylline, NAD nucleosidase, 492 

 Thetin:homocysteine transmethylase, a- 



nalogs, 356-357 

 Thiaminase, analogs, 523-525 

 Thiamine, 



analogs of, see also Oxythiamine, Pyri- 

 thiamine, and others, 514-534, 



central nervous system, 527, 530-531 

 enzyme inhibitions, 518-519 

 growth of microorganisms, 528-530 

 mechanisms of action, 532-534 

 metabolic disturbances by, 533-534 

 neuromuscular function, 531 

 phosphorylation of, 519 

 pyruvate accumulation, 520-521 

 resistance to, 528-529 

 sites of action, 516 

 structures of, 517 

 summary of actions, 532 

 thiaminase, 523-525 

 thiamine deficiency, 530-531 



thiamine kinase, 522-523 

 thiamine levels in tissues, 525-526 

 thiamine-PP levels in tissues, 525-527 

 tissue levels of, 527-528 

 toxicity, 530-531 

 types of, 516-518 

 metabolism of, pathways, 514-515 

 reaction with mercurials, 774 

 urinary excretion of, oxythiamine, 525 



Thiamine disphosphatase, mercurials, 860 



Thiamine disulfide, 

 structure of, 517 

 thiamine kinase, 523 



Thiamine-diphosphate, 



metabolic functions of, 514-516 

 tissue levels of, analogs, 525-527 



Thiamine kinase, 

 analogs, 522-523 



role of inhibition in toxicity of, 532- 

 533 

 nucleotides, 475 



Thiazole-pyrophosphate, see also 4-Me- 

 thyl-5-hydroxyethylthiazole-PP, struc- 

 ture of, 517 



Thiazolidine rings, reactivity of enzyme 

 SH groups, 644, 646 



Thiazoline rings, reactivity of enzyme SH 

 groups, 644, 646 



/3-2-Thienylalanine, 



phenylalanine hydroxylase, 354 

 L-phenylalanine:sRNA ligase (AMP), 

 354 



Thienylglycine, glycine uptake by ascites 

 cells, 265 



Thimerosal (Merthiolate), structure of, 

 970 



Thiobacillus thiooxidans, 



CO2 fixation, mercurials, 892 

 respiration (endogenous), malonate, 168 



Thioesters, splitting by mercurials, 751 



Thioglycolate, glutathione oxidase, 593 



Thioglycosidase, glucono-l,4-lactone, 429 



6-Thioinosinemonophosphate, IMP dehy- 

 drogenase, 471, 481 



Thiol-disulfide equilibria, 639, 656 



Thiols, see also Sulfhydryl groups, 

 equilibria with disulfides, 639, 656 

 role in metabolism, 636-637 



