HAEMOSPORIDIA 



603 



Fig. 257. Exoerythrocytic schizogony in avian Plasmodium, a-f, P. 

 gallinaceum in smears from chicks (James and Tate), a, monocyte from 

 lung, infected by 2 young schizonts; b, monocyte from liver, with a grow- 

 ing trinucleate schizont; c, monocyte from lung, with a large multi- 

 nucleate schizont; d, large mature schizont containing many mature mero- 

 zoites, free in lung; e, portion of broken schizont from lung, showing the 

 attached developing merozoites. ( X1660). f, a capillary of brain blocked 

 by 3 large schizonts ( X740). g, h, P. cathemerium in sections of organs of 

 canaries (Porter; X1900). g, capillary in the brain, showing an endothelial 

 cell infected with a uninucleate and a multinucleate schizont; h, a multi- 

 nucleate schizont and a group of merozoites found in a capillary of heart 

 muscle. 



cynomolgi, Shortt and Garnham report that the E.-E. stages occur 

 in the parenchymatous cells of the liver of host monkeys and are in- 

 clined to think that there is one generation only. The earliest forms 

 were seen on the fifth day after the inoculation of the sporozoites. 

 They are rounded bodies, about 10m in diameter and contain about 

 50 chromatin granules of irregular shape. They grow in size to about 

 35m in diameter, and divide in eight to nine days into some 1000 

 merozoites, each measuring about 1/z. These merozoites presumably 

 invade the erythrocyte. In P. vivax, the E.-E. stages develop in the 

 parenchymatous cells of the liver also and resemble those of P. 

 cynomolgi. The forms found on the seventh day after sporozoite- 

 inoculation were slightly larger (about 42/z in diameter) than those 



