28 



An Introduction to Medical Mycology 



of T. gypseum and of T. purpureum. Conversely, patients with infections 

 due to T. purpureum who did not react to an extract made from that 

 organism failed to react to a vaccine made from T. gypseum. Similarly, one 

 may observe the variations (usually minor) which occur when two com- 

 mercial trichophytins are administered to the same patients. A study of 



TABLE 2.— Reaction to Trichophytin and Catarrhal Vaccine of Patients with 

 Strong Reaction to Oidiomycin* 



Patient 



Oidiomycin 



48 Hr. 



lWk. 



Trichophytin 



IS ||i-. 



lWk. 



Catarrhal Vaccine 



48 Hr. 



lWk. 



B.B. 

 R.E. 



T.E. 



W.F. 



G.B. 



A.Y. 



D.C. 



G.R. 



S.I. 



M.I. 

 G.P. 



S.E. 



D.J 

 K.J 

 S.J. 



M.S. 

 D.A. 

 M.I. 

 D.R. 

 A.Y. 



+ + + 



+ + + 



+ + + 



+ + + 



+ + + 



+ + + 



+ + 



+ + + 



+ + + 



+ + + 



+ + + 



+ + + 



+ + 



+ + 



+ + 



+ + 



+ + 

 + + 



+ 



+ 

 O 

 O 



+ + 



o 



+ + + 



+ + + 



o 



+ + + 



+ 



+ + 



+ + 



+ 



o 



+ + 

 + 



o 

 o 

 o 

 o 



+ + 

 o 

 o 



+ 



o 



+ + 

 + 

 + 

 o 



+ 

 + 

 o 

 o 



o 



+ + 

 o 

 o 

 + 

 + 

 o 

 o 

 + 

 + 

 o 

 + 

 o 

 o 



+ + 

 o 

 o 



o 



+ + 



+ + + 



o 



+ + + 



+ + 



+ + 



o 

 o 

 o 

 o 



o 

 o 



+ 

 o 

 o 

 o 



+ + 

 o 



o 



o 

 o 

 o 



o 

 o 

 o 

 o 

 o 



Total 



patients 20 

 Total 

 positive 

 reactions . . . 



19 



11 



6 



'For all patients, fungous examination showed M. albicans. 



these variations has already been published but may be briefly referred to 

 here. Of 57 reactions to one or more of three trichophytins, 53 (93 per 

 cent) were elicited by Metz (1:100), 43 (75 per cent) by Lederle (1:30), 

 and 25 (43 per cent) by Bischoff trichophytin ( dermatomycol undiluted). 

 After additional experience we noted agreement between the Metz and 

 the Lederle trichophytin in 80 to 95 per cent of cases. It would appear that 

 the specificity of the test is chiefly due to the component in the vaccine 

 which is common to all members of the genus. 



