206 An Introduction to Medical Mycology 



believes that antimony in the trivalent form (fnadin) and the pentavalent 

 form (neostam) should receive particular attention. 



BIBLIOGRAPHY 



Chhistie, A., and Peterson, J. C: Pulmonary calcification in negative reactors to tuberculin, 



Am. J. Pub. Health 35:1131, 1945. 

 Conant, N. F.: Cultural study of the life-cycle of Histoplasma capsulatum Darling 1906, 



J. Bact. 41:563, 1941. 

 Darling, S. T. : A protozoon general infection producing pseudi (tubercles and focal necrosis 



in liver, spleen and lymph nodes, J. A. M. A. 46:1283, 1906. 

 DeMonbreun, W. A.: Cultivation and cultural characteristics of Darling's Histoplasma cap- 

 sulatum, Am. J. Trop. Med. 14:93, 1934. 

 Henderson, R. C; Pinkerton, H., and Moore, L. T.: Histoplasma capsulatum as cause 



of chronic ulcerative enteritis, J. A. M. A. 118:885, 1942. 

 Meleney, H. E.: Histoplasmosis ( reticuloendothelial cytomycosis), Am. J. Trop. Med. 20:603, 



1940; Histoplasmosis, New York State J. Med. 42:346, 1942. 

 Miller, H. E.; Keddie, F. M.; Johnstone, H. C, and Bostick, W. L.: Histoplasmosis: 



Cutaneous and mucomembranous lesions; mycologic and pathologic observations, Arch. 



Dermat. & Syph. 56:715, 1947. 

 Palmer, A. E.; Amolsch, A. L., and Shaffer, L. W.: Histoplasmosis with mucocutaneous 



manifestations: Report of case, Arch. Dermat. & Syph. 45:912, 1942. 

 Palmer, C. E.: Nontuberculous pulmonary calcification and sensitivity to histoplasmin, Pub. 



Health Rep. 60:513, 1945. 



7. COCCIDIOIDOMYCOSIS 



This appears as an acute infection or in the form of granuloma coc- 

 cidioides. The majority of cases of this disorder originate in the San Joaquin 

 Valley and Los Angeles County, California, and for this reason it is famil- 

 iarlv known as the California disease. There have been scattered cases in 

 the Middle and Southwestern States, but in most instances the patients had 

 lived in California. Smith stated that in a number of cases the disease origi- 

 nated near El Paso, Texas; Farness reported five cases of the disease from 

 Arizona and the remarkable fact that 90 per cent of the Indians in the Pima 

 Reservation gave positive reactions to the coccidioidin test. Reports from 

 other sections make it apparent that the organism may be more widely dis- 

 tributed than is ordinarily thought. Credit for the first description of the 

 condition is usually given to Rixford, who reported his findings in 1894. 

 Cases of a disease with similar features reported from South America are 

 instances of a different disease (granuloma Paracoccidioides). 



(a) Period of incubation.— This is between one and two weeks. In an 

 instance of laboratory infection reported by Dickson the period of incuba- 

 tion was seven days. 



(1)) Etiology.— The causal micro-organism is C. immitis. This fungus 

 has been isolated from soil, from vegetation and from the internal organs 

 of slaughtered cattle and sheep. Ashburn and Emmons found fungi in 25 



