The Deep Mycoses (Essentially or Potentially Systemic) L85 



b. Copper sulfate. This is <>l dubious value; \ ur. (0.016 Gm.) ma\ be 

 given 1>\ inoiitli, or colloidal copper ma\ be administered intravenously. 



(. Local treatment. This should consist ol irrigation ol the sinuses with 

 compound solution ol iodine (Lugol's solution), diluted, or with a 1 per 

 cent aqueous solution ol gentian violet. Packing the sinus tracts with for- 

 maldehyde gauze lias also been advocated. 



D. Surgical intervention. Accessible lesions may he completer) excised or 

 incised to pro\ ide irrigation. 



e. Thymol. Preliminary experiments In Myers showed that a 1:1,000 

 aqueous solution of thymol possesses the power of destroying Actinomyces 

 in 45 seconds. Myers treated five patients with thymol locally and sys- 

 tenucallv, and all recovered. A patient who refused to take thymol inter- 

 nally died of visceral involvement. For local use, Myers used a 10 to 20 

 per cent solution of thymol in olive oil. For internal use, thymol was ad- 

 ministered 1>> mouth in crystal form in 1 or 2 Gm. capsules once daily or 

 less frequently. It was given on an empty stomach. While the small number 

 of patients who have been treated with thymol does not allow fair evalua- 

 tion of its worth, we are of the opinion that it has merit and may be used 

 for patients intolerant to the drugs advocated in the preferred schedule. 



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