212 An Introduction to Medical Mycology 



(2) Iodide therapy— This usually appears to be ineffective. Some of the 

 reports of improvement were probably due to an erroneous diagnosis 

 ( blastomycosis ) . 



(-3) Injection of colloidal copper.— Although it has been advocated, this 

 treatment is not in common use. The dose is 5 cc. administered intramus- 

 cularly every four to seven days. 



(4) Specific vaccinotherapy .— This has also been reported to be effective. 

 Anderson stated that Jacobson of Los Angeles achieved good results in 

 apparently hopeless cases, corroborating his earlier claims of success. 



(5) Gentian violet.— This may be used locally in a 1 per cent aqueous 

 solution and intravenously in a 0.25 per cent solution, the total dose consist- 

 ing of 5 mg. of the dye per kilogram of body weight ( Pulf ord and Larson ) . 

 If this is exceeded, toxic symptoms may develop. 



(6) Antimony and potassium tartrate— The dose is from 2 to 8 cc. of a 

 1 per cent solution given intravenously. Guy and Jacob, and Tomlinson 

 and Bancroft used this drug in combination with roentgen rays, reporting 

 good results in three patients. 



(7) Thymol— The effect of this drug has been investigated by Cox and 

 Dickson. In the experimental animal it was found to be superior to all 

 other drugs which they tested, and a clinical trial in a patient was followed 

 by apparent cure. A 33.3 per cent solution in olive oil was applied locally, 

 and doses of 1 to 6 Gm. daily, dissolved in olive oil and placed in capsules, 

 were taken with meals. 



BIBLIOGRAPHY 



Anderson, N. P.: Discussion, J. Invest. Dermat. 4:480, 1941. 



Ashburn, L. L., and Emmons, C. W.: Spontaneous coccidioidal granuloma in lungs of wild 



rodents, Arch. Path. 34:791, 1942. 

 Cooke, J. V.: Immunity tests in coccidioidal granuloma, Arch. Int. Med. 15:479, 1915. 

 Cox, H. C, and Dickson, E. C: Experimental therapy in coccidioidal granuloma, j. A. M. A. 



106:777, 1936. 

 Cummins, W. J.; Smith, J. K., and Halliday, C. EL: Coccidioidal granuloma: Epidemiologic 



survey with report of 24 additional cases, J. A. M. A. 93:1046, 1929. 

 Dickson, E. C: Coccidioidomycosis: Preliminary acute infection with fungus Coccidioides, 



J. A. M. A. 111:1362, 1938. 

 Evans, N., and Ball, H. A.: Coccidioidal granuloma: Analysis of 50 cases, J. A. M. A. 93:1881, 



1929. 

 Farness, O. J.: Coccidioidomycosis, J. A. M. A. 116:1749, 1941. 

 [acobson, II. P.: Fungous Diseases: A Clinico-Mycologicai Text (Springfield, 111.: Charles C 



Thomas, Publisher, 1932). 

 Ophuls, in discussion on Pulford and Larson. 



Pulford, D. S., and Labson, E. K.: Coccidioidal granuloma, J. A. M. A. 93:1049, 1929. 

 Rixford, E.: Case of protozoic dermatitis, Occidental M. Times 8:704, LS94; Two casts 



of protozoan (coccidioidal) infection of skin, Johns Hopkins Ilosp. Rep. 1:209, 1896. 

 Smith, C. E.: Epidemiology ol acute coccidioidomycosis with erythema nodosum, Am. J. 



Pub. Health 30:000. L940. 





