THE HORMONES IN HUMAN REPRODUCTION 



With the foregoing explanation the reader, if he is stiU 

 curious about these relationships and wishes to follow out such 

 problems as the synthesis of estrone, is now in a position to 

 study a more technical discussion of the chemistry of the 

 estrogenic hormones such as E. A. Doisy gives in Sex and 

 Internal Secretions,* 



The androgenic hormones. These may be understood by 

 reference to their basic hydrocarbon, androstane, which dif- 

 fers from estrane by having a second methyl group, attached 



to carbon 10: 



CH. 



ANDROSTANE 



Androsterone, referred to in Chapter IX, as the hormone of 

 male type first isolated from human urine, is 3-hydroxy, 17- 

 keto androstane: ^^ 



o =0 



ANDROSTERONE 



2 Sex and Internal Secretions, edited by Edgar Allen, 2d edition, 

 Baltimore, Williams and Wilkins, 1939. Chapter XIII, "Biochemistry of 

 the Estrogenic Compounds," by E. A. Doisy. 



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