THE HORMONES IN HUMAN REPRODUCTION 



eye-grafts, by withdrawal of either the estrogenic hormone 

 or progesterone, he observes the same sequence of blanching 

 and hemorrhage that occurs in spontaneous menstruation. 

 If the monkey is given progesterone, the graft will bleed 

 from a "premenstrual" state; if given estrogenic hormone, 

 it bleeds from the interval state. 



With this information in hand it is possible to plan an 

 experiment in imitation of the normal ovulatory cycle. This 

 is represented in the upper half of the following diagram, 

 Fig. 27. The underlying idea occurred to workers in the 

 Oxford, Harvard, and Rochester (N.Y.) laboratories at 



Progesterone during a. courae of estrin: 



I estrin 

 I 500 Inl.U. 



cslrinl25Int.U. progesterone Im^. i ^^ 



deiilij dadlv -^ 

 ?tz"^r:2i~z?-'zr^irTi2i ! 



\ 



\ bleeding 



CASTRATE X 



Currenl: hijpothesis of ovulalorij incnslruation: 



corpus luteum rclro^ressca n 

 -progesterone acting —^ J 

 X — X — X — x — X — »t — ^ — y^ 



resenrioQcL \ 



effective on 

 enxioimetri-u-na 



INTACT 



\ 



-- inetfective 



V 



\ 



^•-^ 



Fig. 27. The upper figure illustrates the production of bleeding after 

 discontinuance of a course of progesterone, in spite of continued and 

 more intensive estrogen treatment. The dosage shown is that of the 

 author's experiments (Corner, 1937, 1938) ; similar results were obtained 

 by Zuckerman, 1937, and by Hisaw and Greep, 1938. 



{ 166 } 



