THE HORMONES IN HUMAN REPRODUCTION 



Note 15 (page 185, line 34). Amount of progesterone 

 secreted daily in the human. It is now known that by no 

 means half the progesterone that gets into the blood is ex- 

 creted in the urine as pregnanediol. If a measured amount 

 of progesterone is administered by injection, only about 10 

 to 15% of it appears as pregnanediol. On the basis of such 

 results G. Van S. Smith and O. W. Smith, Seeger-Jones and 

 Te Linde, and others now estimate that the corpus luteum 

 secretes about 50 milligrams of progesterone per day at the 

 peak of its cyclic activity. 



Note 16 (page 194, line 33). Amount of estrogen produced 

 daily in the human. G. Van S. Smith, O. W. Smith, and Sara 

 Schiller, American Journal of Obstetrics and Gynecology, 

 vol. 44, pp. 605-615, 1943, published an estimate based ad- 

 mittedly on a number of unproved assumptions concerning 

 the metabolism of the estrogens. Their result, 0.08 to 0.70 

 milligrams, averaging 0.33 mg., is not far from that reached 

 by my totally different method of estimation ; my figure, ex- 

 pressed as estrone, is equivalent to 0.30 milligrams. 



Note 17 (page 211, line 12). The isolation and identifica- 

 tion of prolactin. Two months after these Vanuxem lectures 

 were delivered. White, Bonsnes, and Long of Yale University 

 announced success in the isolation from beef pituitary glands 

 of a crystalline substance of high lactogenic activity. The 

 hormone is a protein of high molecular weight (32,000 or 

 more). Readers with a knowledge of biochemistry will be in- 

 terested in their account of their own work and that of 

 Lyons and other investigators upon which their efforts were 

 partly based. {Journal of Biological Chemistry, vol. 143, 

 1942, pp. 447-464). 



Note 18 (page 228, last line of footnote). Berthold's 

 article. A translation of the original paper into English, by 



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