APPENDIX I 



The preparation of progesterone from pregnanediol and 

 from stigmasterol (a natural vegetable sterol) and other 

 chemical matters of interest concerning progesterone and its 

 related substances are fully discussed by W. M. Allen in 

 Sex and Internal Secretions. 



As explained in Chapter V, when pregnanediol leaves the 

 body in the urine, it does so in combination with glycuronic 

 acid and with sodium. The resultant compound, sodium preg- 

 nanediol glycuronidate, has the following structure : 



CH3 H\ 



u 



H H H 



C — C — C — C— COONa 



OHO 



H H 



SODIUM PREGNANEDIOL GLYCURONIDATE 



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