APPENDIX II 



Note 1 (Preface, page x, line 30). Bibliographic refer- 

 CTices. Full bibliographies covering practically the whole field 

 of this book will be found in : 



Sex and Internal Secretions, edited by Edgar Allen, 2d 



edition, Baltimore, 1939. 

 Glandular Physiology and Therapy , 2d edition, Chicago, 



1942. 

 Biological Actions of Sex Hormones, by Harold Bur- 

 rows, Cambridge, England, 1945. 

 Endocrinologie de la Gestation, by Robert Courrier, 



Paris, 1945. 

 Patterns of Mammalian Reproduction, by S. A. Asdell, 

 Ithaca, N.Y., 1946. 



Note 2 (page 64, line 32). The Atlantic palolo. An in- 

 teresting account of the swarming of an Atlantic species 

 closely related to the oft-cited palolo of the Pacific Ocean, 

 has recently been published by L. B. Clark and W. N. Hess, 

 "Swarming of the Atlantic Palolo W6rm," Carnegie Institu- 

 tion of Washington^ Publication d'^l).. Papers from the 

 Tortugas Laboratories, vol. xxxiii, 1943. 



Note 3 (page 96, line 24). Action of the sex-gland hor- 

 mones on the embryonic sex organs. Since the preparation 

 of these lectures, there has been a considerable clarification 

 of our knowledge of the action of the estrogens and of the 

 male hormones (androgens) upon the growth of the accessory 

 sex organs of the embryo and in particular upon their differ- 

 entiation into male and female types. 



Stating the fundamentals of the problem briefly, the 

 original determination of the sex of an individual mammalian 

 animal is made at the time of fertilization of the Qgg, by a 

 mechanism which operates through the chromosomes of the 

 ^gg- and sperm-nucleus. No visible difference between the 

 sexes appears however until the embryo reaches an age (in the 



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