THE HORMONES IN HUMAN REPRODUCTION 



maintenance. To fit it for gestational functions, the endocrine 

 mechanism of the corpus luteum was evolved. In the light of 

 this thought it is not surprising that the uterine chamber is 

 actually a less favorable place for early embryos than, say, 

 the anterior chamber of the eye, except when the hormones of 

 the ovary act upon it and change it into a place of superior 

 efficiency for its new function. 



Note 5 (page 118, line 11). Progestin by mouth. The pro- 

 gesterone-like substance that can be administered orally is 

 called pregneninolone (preg-nene-in-ol-one) or ethinyl testos- 

 terone. Its chemical structure is 



o^ 



PREGNENINOLONE 



Note 6 (page 122, line 6). Excretion products of pro- 

 gesterone. The statement in the text is not quite correct. 

 Marker, Wittle, and Lawson have found pregnanediol in the 

 urine of pregnant cows and mares, in concentrations not 

 greatly different from those in human pregnancy urine. They 

 found, strangely, that the urine of bulls contains about twice 

 as much pregnanediol as human pregnancy urine. It un- 

 fortunately remains true that the end-products of pro- 

 gesterone metabolism have not been identified in the common 

 laboratory animals. 



Note 7 (page 126, line 2). /« the corpus luteum necessary 

 throughout pregnancy? Experiments on the Rhesus monkey 

 by C. G. Hartman and G. W. Corner, which were under way 

 when the first edition of this book was published, have been 



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