APPENDIX II 



completed (Anatomical Record, vol. 98, August 1947). They 

 prove that the corpus luteum of pregnancy, and probably the 

 whole of the ovarian tissue, can in this species be removed as 

 early as the 25th day of pregnancy without disturbing 

 gestation. 



Note 8 (page 132, line 11). Clinical use of progesterone 

 and pregneninolone. Five years after these pages on the 

 practical use of progesterone were first written, they may be 

 reprinted with little or no modification. The same hopes, the 

 same successes, the same cautions, still stand. Some progress 

 has been made in selecting cases suitable for progesterone 

 therapy, thanks to the use of pregnanediol excretion as a test 

 of the need for progesterone. In the large university hospitals, 

 where there are laboratories in the women's clinics equipped 

 for the assay, only those cases of habitual abortion and of 

 menorrhagia that show a low excretion of pregnanediol are 

 treated with progesterone or pregneninolone. In these selected 

 cases, naturally, the percentage of favorable results is higher 

 than when all cases of a given disease are treated on a hit-or- 

 miss basis. 



Sterility, when there is similar evidence that a low pro- 

 gesterone level is involved, is to be added to the list of patho- 

 logical conditions in which progestin therapy is now being 

 tried. 



Note 9 (page 135, line 24). Menstruation in lower pri- 

 mates. Evidence has accumulated that something like men- 

 struation, in an elementary form at least, occurs in the New 

 World monkeys. In several vspecies of howler, spider and 

 capuchin monkeys there is periodic shedding of small amounts 

 of blood into the tissue of the lining of the uterus. A few red 

 blood cells escape into the genital canal and can be detected 

 in washings made by injecting salt solution into the vagina, 

 removing it again and examining it under the microscope. 

 There is not enough blood lost to show externally. 



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